Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC013
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-14 14:07
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Mirapexin 2,1mg; PK Merz 100mg 2x1; tbl Rivotril 2mg 2x1/4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.66 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.66 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 11, 'TN': 10, 'TP': 31, 'FP': 20}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 10, 'TN': 11, 'TP': 32, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 4, 'TN': 2, 'TP': 38, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 2.18
timePerCircleCoV 0.122706
timePerCircleSlope -0.010342
meanError 3.53249
tremorFreq 6.83594
tremorRelPower 22.3878
tremorGyroAmpMean 0.0506671
tremorGyroAmpSlope -0.0215629
tremorGyroAmpCoV 0.262978
tremorCoordAmpMean 0.116984
tremorCoordAmpSlope -0.0205899
tremorCoordAmpCoV 0.20698
tremorAccAmpMean 0.0826446
tremorAccAmpSlope -0.0254916
tremorAccAmpCoV 0.31811
tremorPcRelVar 0.666766
tremorPcX -0.279756
tremorPcY 0.960071

Circle Segment 1

Duration 2.88 s, Accuracy Estimate 2.636 (lower is better)

Circle Segment 2

Duration 2.12 s, Accuracy Estimate 3.255 (lower is better)

Circle Segment 3

Duration 2.0 s, Accuracy Estimate 3.947 (lower is better)

Circle Segment 4

Duration 2.0 s, Accuracy Estimate 3.87 (lower is better)

Circle Segment 5

Duration 1.96 s, Accuracy Estimate 2.959 (lower is better)

/usr/local/lib/python3.9/site-packages/scipy/signal/_spectral_py.py:2014: UserWarning: nperseg = 400 is greater than input length  = 392, using nperseg = 392
  warnings.warn('nperseg = {0:d} is greater than input length '

Circle Segment 6

Duration 2.04 s, Accuracy Estimate 3.309 (lower is better)

Circle Segment 7

Duration 2.12 s, Accuracy Estimate 3.7 (lower is better)

Circle Segment 8

Duration 2.24 s, Accuracy Estimate 4.998 (lower is better)

Circle Segment 9

Duration 2.28 s, Accuracy Estimate 3.194 (lower is better)

Circle Segment 10

Duration 2.16 s, Accuracy Estimate 3.455 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 14.044
timePerSpiralCoV 0.154098
timePerSpiralSlope 0.0349896
meanError 2.01443
tremorFreq 7.42188
tremorRelPower 33.0126
tremorGyroAmpMean 0.0425917
tremorGyroAmpSlope 4.55162e-05
tremorGyroAmpCoV 0.366466
tremorCoordAmpMean 0.0875054
tremorCoordAmpSlope 1.0782e-05
tremorCoordAmpCoV 0.320804
tremorAccAmpMean 0.075938
tremorAccAmpSlope 0.000564685
tremorAccAmpCoV 0.361756
tremorPcRelVar 0.758701
tremorPcX -0.678506
tremorPcY -0.734594

Spiral Segment 1

Duration 10.84 s, Accuracy Estimate 2.067 (lower is better)

Spiral Segment 2

Duration 12.04 s, Accuracy Estimate 2.1 (lower is better)

Spiral Segment 3

Duration 14.0 s, Accuracy Estimate 2.105 (lower is better)

Spiral Segment 4

Duration 12.24 s, Accuracy Estimate 2.171 (lower is better)

Spiral Segment 5

Duration 13.44 s, Accuracy Estimate 2.059 (lower is better)

Spiral Segment 6

Duration 14.28 s, Accuracy Estimate 1.994 (lower is better)

Spiral Segment 7

Duration 18.6 s, Accuracy Estimate 2.228 (lower is better)

Spiral Segment 8

Duration 15.32 s, Accuracy Estimate 1.7 (lower is better)

Spiral Segment 9

Duration 15.36 s, Accuracy Estimate 1.654 (lower is better)

Spiral Segment 10

Duration 14.32 s, Accuracy Estimate 2.066 (lower is better)

Elel

eDurationMean 0.256184
eDurationStd 0.0303456
eDurationStdnorm 0.118452
eDurationMedian 0.255
eDurationQuartdelta 0.025
eDurationQuartdeltanorm 0.0980392
eDurationKurt 12.674
eDurationTrenddiff -0.02
eDurationTrendratio 0.923077
eWidthMean 3.87024
eWidthStd 0.93536
eWidthStdnorm 0.24168
eWidthMedian 3.861
eWidthQuartdelta 1.053
eWidthQuartdeltanorm 0.272727
eWidthKurt 3.21409
eWidthTrenddiff -0.702
eWidthTrendratio 0.837838
eHeightMean 11.0873
eHeightStd 1.30949
eHeightStdnorm 0.118108
eHeightMedian 10.9395
eHeightQuartdelta 1.521
eHeightQuartdeltanorm 0.139037
eHeightKurt 3.077
eHeightTrenddiff -0.819
eHeightTrendratio 0.927835
eAspectMean 0.347186
eAspectStd 0.0661876
eAspectStdnorm 0.19064
eAspectMedian 0.352904
eAspectQuartdelta 0.0783626
eAspectQuartdeltanorm 0.222051
eAspectKurt 2.81795
eAspectTrenddiff -0.0132791
eAspectTrendratio 0.962879
eSlantMean -0.0488224
eSlantStd 0.106381
eSlantStdnorm -2.17894
eSlantMedian -0.028553
eSlantQuartdelta 0.127551
eSlantQuartdeltanorm -4.46717
eSlantKurt 5.88001
eSlantTrenddiff 0.0207885
eRtopMean 0.794724
eRtopStd 0.11254
eRtopStdnorm 0.141609
eRtopMedian 0.809476
eRtopQuartdelta 0.151515
eRtopQuartdeltanorm 0.187177
eRtopKurt 3.27097
eRtopTrenddiff 0.0720288
eRbotMean 0.988022
eRbotStd 0.399238
eRbotStdnorm 0.404078
eRbotMedian 0.854497
eRbotQuartdelta 0.295833
eRbotQuartdeltanorm 0.346207
eRbotKurt 11.3643
eRbotTrenddiff 0.121795
eRrightMean 0.903501
eRrightStd 0.0514688
eRrightStdnorm 0.0569659
eRrightMedian 0.915212
eRrightQuartdelta 0.0516129
eRrightQuartdeltanorm 0.0563945
eRrightKurt 4.43071
eRrightTrenddiff 0.0293317
eRleftMean 0.382476
eRleftStd 0.0879311
eRleftStdnorm 0.2299
eRleftMedian 0.383333
eRleftQuartdelta 0.0953904
eRleftQuartdeltanorm 0.248845
eRleftKurt 3.2067
eRleftTrenddiff -0.0150794
lDurationMean 0.3595
lDurationStd 0.0475934
lDurationStdnorm 0.132388
lDurationMedian 0.36
lDurationQuartdelta 0.06
lDurationQuartdeltanorm 0.166667
lDurationKurt 2.93416
lDurationTrenddiff -0.05
lDurationTrendratio 0.86755
lWidthMean 7.13992
lWidthStd 1.30756
lWidthStdnorm 0.183134
lWidthMedian 6.9615
lWidthQuartdelta 1.287
lWidthQuartdeltanorm 0.184874
lWidthKurt 3.71801
lWidthTrenddiff -0.117
lWidthTrendratio 0.983471
lHeightMean 27.2756
lHeightStd 3.71021
lHeightStdnorm 0.136027
lHeightMedian 26.091
lHeightQuartdelta 4.8555
lHeightQuartdeltanorm 0.186099
lHeightKurt 3.90073
lHeightTrenddiff -4.7385
lHeightTrendratio 0.839286
lAspectMean 0.263039
lAspectStd 0.0410481
lAspectStdnorm 0.156053
lAspectMedian 0.270168
lAspectQuartdelta 0.0522232
lAspectQuartdeltanorm 0.193299
lAspectKurt 4.09196
lAspectTrenddiff 0.0292195
lAspectTrendratio 1.11677
lSlantMean -0.0526156
lSlantStd 0.0635201
lSlantStdnorm -1.20725
lSlantMedian -0.0417749
lSlantQuartdelta 0.0927658
lSlantQuartdeltanorm -2.22061
lSlantKurt 3.77982
lSlantTrenddiff 0.0367828
lRtopMean 0.768589
lRtopStd 0.0972212
lRtopStdnorm 0.126493
lRtopMedian 0.745514
lRtopQuartdelta 0.145278
lRtopQuartdeltanorm 0.19487
lRtopKurt 2.32641
lRtopTrenddiff 0.0546512
lRbotMean 0.99816
lRbotStd 0.254262
lRbotStdnorm 0.254731
lRbotMedian 0.956598
lRbotQuartdelta 0.302433
lRbotQuartdeltanorm 0.316155
lRbotKurt 9.7608
lRbotTrenddiff -0.0855959
lRrightMean 0.896188
lRrightStd 0.0449383
lRrightStdnorm 0.0501439
lRrightMedian 0.896113
lRrightQuartdelta 0.0667792
lRrightQuartdeltanorm 0.0745209
lRrightKurt 2.36066
lRrightTrenddiff 0.0494781
lRleftMean 0.44443
lRleftStd 0.0924396
lRleftStdnorm 0.207996
lRleftMedian 0.437587
lRleftQuartdelta 0.0963285
lRleftQuartdeltanorm 0.220136
lRleftKurt 3.72949
lRleftTrenddiff -0.0547823

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.95
sumTouchScores 23.75
meanMovementTime 0.729167
numTouches 25
undershootPercentage 4
overshootPercentage 8

FITTS Long Modified

meanTouchScore 0.947368
sumTouchScores 18
meanMovementTime 1.015
numTouches 19
undershootPercentage 5.26316
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 9.928
timePerZigzagCoV 0.0941617
timePerZigzagSlope -0.016116
meanError 2.71715
tremorFreq 7.61719
tremorRelPower 33.7877
tremorGyroAmpMean 0.0657571
tremorGyroAmpSlope -0.00260744
tremorGyroAmpCoV 0.265807
tremorCoordAmpMean 0.149076
tremorCoordAmpSlope -0.00418676
tremorCoordAmpCoV 0.338758
tremorAccAmpMean 0.132412
tremorAccAmpSlope -0.00265945
tremorAccAmpCoV 0.312009
tremorPcRelVar 0.628015
tremorPcX 0.663969
tremorPcY 0.74776

ZigZag Segment 1

Duration 11.28 s, Accuracy Estimate 3.271 (lower is better)

ZigZag Segment 2

Duration 8.64 s, Accuracy Estimate 2.952 (lower is better)

ZigZag Segment 3

Duration 9.96 s, Accuracy Estimate 2.353 (lower is better)

ZigZag Segment 4

Duration 9.92 s, Accuracy Estimate 2.546 (lower is better)

ZigZag Segment 5

Duration 9.84 s, Accuracy Estimate 2.464 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 7.024
timePerZigzagCoV 0.0492523
timePerZigzagSlope -0.0182232
zigzagHeightMean 55.0655
zigzagHeightCoV 0.0578611
zigzagHeightSlope -0.010071
meanError 0.041439
tremorFreq 7.03125
tremorRelPower 36.9361
tremorGyroAmpMean 0.0772815
tremorGyroAmpSlope -0.00119523
tremorGyroAmpCoV 0.283157
tremorCoordAmpMean 0.144918
tremorCoordAmpSlope 0.00710475
tremorCoordAmpCoV 0.24174
tremorAccAmpMean 0.116294
tremorAccAmpSlope 0.00895665
tremorAccAmpCoV 0.274341
tremorPcRelVar 0.665347
tremorPcX 0.936605
tremorPcY 0.350388

ZigZag Offset Segment 1

Duration 7.12 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 2

Duration 7.04 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 3

Duration 7.44 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 7.04 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 5

Duration 6.48 s, Accuracy Estimate 0.061 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.76}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.66}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.7245270959101151}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.10387606812028305}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}